People need to be recommended to measure Promethazine with Codeine Oral Resolution with an accurate measuring unit. A house teaspoon is not really an precise measuring system and may lead to overdosage, especially when a 50 % a teaspoon is measured.
Postmarketing instances of respiratory melancholy, which includes fatalities have already been documented with usage of promethazine in pediatric individuals.
Do not flush medicines down the rest room or pour them into a drain Except if instructed to take action. Appropriately discard this product when it is expired or no more needed. Talk to your pharmacist or nearby waste disposal organization.
Tend not to abruptly discontinue Promethazine with Codeine Oral Resolution in a very bodily-dependent affected person. When a individual who has long been taking Promethazine with Codeine Oral Alternative often and should be bodily dependent now not requires therapy with Promethazine with Codeine Oral Option, taper the dose gradually, by 25% to 50% each and every 2 to 4 days, although monitoring cautiously for signals and signs and symptoms of withdrawal.
Talk to your Health care supplier if you have any questions about this information and facts. Before you take PROMETHAZINE WITH CODEINE ORAL Option, tell your Health care provider about your entire healthcare ailments, which includes if you: Use a drug habit
Dosing glitches may end up in accidental overdose and death. To scale back the risk of overdose and respiratory depression, make certain that the dose of Promethazine with Codeine Oral Remedy is communicated Obviously and dispensed accurately [see Dosage and Administration ( 2.one) ]. Recommend sufferers to usually use an accurate milliliter measuring unit when measuring get more info and administering Promethazine with Codeine Oral Option. Notify people that domestic teaspoon just isn't an accurate measuring unit and this sort of use may lead to overdosage and severe adverse reactions [see ]. For prescriptions where a measuring system is not delivered, a pharmacist can provide an ideal calibrated measuring gadget and can provide instructions for measuring the right dose.
The mix of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric individuals under six decades of age. Concomitant administration of promethazine products with other respiratory depressants has an association with respiratory despair, and sometimes Demise, in pediatric clients. The association does in a roundabout way relate to individualized fat-dependent dosing, which might in any other case permit Harmless administration.
Since Promethazine VC with Codeine is utilised when wanted, you may not be on a dosing schedule. Skip any skipped dose if it's Just about time to your up coming dose. Tend not to use two doses at a person time.
Codeine in oral therapeutic dosage won't normally exert important effects on the cardiovascular method.
Codeine Codeine is surely an opioid agonist reasonably selective for that mu-opioid receptor, but with a A great deal weaker affinity than morphine. The analgesic and antitussive properties of codeine happen to be speculated to come from its conversion to morphine.
The following critical adverse reactions are described, or explained in larger depth, in other sections:
Acquire this medication specifically as prescribed to decrease the potential risk of addiction. Ask your health care provider or pharmacist For additional information.
Life-threatening respiration challenges (respiratory melancholy). PROMETHAZINE WITH CODEINE ORAL Alternative can cause respiratory complications (respiratory melancholy) that can come about Anytime for the duration of treatment and can cause Dying. Your threat of respiration problems is finest whenever you to start with begin getting PROMETHAZINE WITH CODEINE ORAL Alternative, are taking other medicines that could cause respiratory problems, have specific lung complications, are elderly or have selected other medical problems.
The pharmacokinetics of Promethazine with Codeine Oral Option hasn't been characterized in people with renal impairment. Codeine pharmacokinetics could possibly be altered in patients with renal failure. Clearance can be reduced and the metabolites may possibly accumulate to much increased plasma concentrations in individuals with renal failure as compared to sufferers with normal renal operate.